Diffusing wave spectroscopy and its application for monitoring of skin blood microcirculation

Igor Vladislavovich Meglinski

doi:10.1117/12.518758

13 October 2003 Diffusing wave spectroscopy and its application for monitoring of skin blood microcirculation

Igor Vladislavovich Meglinski

Proceedings Volume 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV; (2003) https://doi.org/10.1117/12.518758
Event: Saratov Fall Meeting 2002 Laser Physics and Photonics, Spectroscopy, and Molecular Modeling III; Coherent Optics of Ordered and Random Media III, 2002, Saratov, Russian Federation

Abstract

Diffusing Wave Spectroscopy (DWS) is a novel modern technique uniquely suited for the non-invasive measurements of the particles size and their motion within the randomly inhomogeneous highly scattering and absorbing media, including biological tissues as a human skin. The technique is based on the illuminating the media (tissues) with a coherent laser light, and analyzing the loss of coherence of the scattered field arises from motion of the scattering particles with respect to each other. Both theoretical and experimental results has shown the potentialities and viability of DWS application for the express non-invasive quantitative monitoring and functional diagnostics of skin blood microcirculation, with down to 1 μm/sec resolution. This is likely lead to quantitative monitoring in general diagnostics, diabetes studies, pharmacological intervention for the failing surgical skin flaps or replants, blood microcirculation monitoring during sepsis, assess burn depth, diagnose atherosclerotic disease, and investigate mechanisms of photodynamic therapy for cancer treatment. In frame of current report we describe the recent developments of DWS further to the point that skin blood micro-flow can be routinely and accurately obtained in a separate skin vascular bed on normal skin tissues.

Citation Download Citation

Igor Vladislavovich Meglinski "Diffusing wave spectroscopy and its application for monitoring of skin blood microcirculation", Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); https://doi.org/10.1117/12.518758

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