Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

Subhadra Srinivasan; Brian W. Pogue; Shudong Jiang; Hamid Dehghani; Keith D. Paulsen

doi:10.1117/12.478219

29 July 2003 Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

Subhadra Srinivasan, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Keith D. Paulsen

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.478219
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Near Infrared diffuse optical tomography was used to measure the molar absorption spectra for de-oxyhemoglobin, oxyhemoglobin and water through phantom experiments. The measured spectra compensate for any systemic errors and errors arising from model-based estimation of concentrations of these chromophores, and show reasonable agreement with existing literature values. The spectra were validated by phantom experiments to obtain the oxygen dissociation curve. Variation of the partial pressure of oxygen in solution yielded results consistent with theory of mean error of 7.6% in estimation of oxygen saturation, and accurate within 5% in estimation of hemoglobin.

Citation Download Citation

Subhadra Srinivasan, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, and Keith D. Paulsen "Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.478219

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available