Development of a time-domain tomographic system for optical imaging

Maria Lepore; Gaetano Urso; Rosario Esposito; Laura Bottalico; M. Esposito; Maria Daniela Falco; Ines Delfino; Pietro Luigi Indovina

doi:10.1117/12.434532

29 June 2001 Development of a time-domain tomographic system for optical imaging

Maria Lepore, Gaetano Urso, Rosario Esposito, Laura Bottalico, M. Esposito, Maria Daniela Falco, Ines Delfino, Pietro Luigi Indovina

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434532
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A multichannel time-resolved system for medical optical tomography has been developed. Its main components are an eight channel single-photon counting detector and an ultrafast picosecond solid state laser. Several instrumental aspects concerning the optical coupling between the MCP-PMT and the optical fiber bundles, the electronic components and the roto-translation stages control have been examined. Moreover the accuracy limits in the determination of optical properties of phantom objects have been largely investigated taking into account the role played by the theoretical description of light propagation, the instrumental response function (by means of a convolution procedure) and the fitting algorithm. Information on image quality parameters (spatial resolution, contrast and SNR) have been also obtained by measuring Edge Response Function in different experimental conditions. In such a work, aqueous Intralipid solutions have been used as phantom objects. Furthermore, experimental investigations on well controlled inhomogeneous with different optical properties embedded in Intralipid solutions have been carried on. As last step of the work, preliminary imaging of cylindrical objects has been performed and a Linux version of TOAST code has been used in the imaging reconstruction.

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Maria Lepore, Gaetano Urso, Rosario Esposito, Laura Bottalico, M. Esposito, Maria Daniela Falco, Ines Delfino, and Pietro Luigi Indovina "Development of a time-domain tomographic system for optical imaging", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434532

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