Noninvasive determination of concentration of compounds in strongly absorbing biological tissue

Rene Alexander Bolt; Johannes Sake Kanger; Frits F. M. de Mul; Xiaomao Wu; Shu-Jen Yeh; Omar S. Khalil

doi:10.1117/12.382729

19 April 2000 Noninvasive determination of concentration of compounds in strongly absorbing biological tissue

Rene Alexander Bolt, Johannes Sake Kanger, Frits F. M. de Mul, Xiaomao Wu, Shu-Jen Yeh, Omar S. Khalil

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382729
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We describe a non-invasive method for the determination of optical parameters of highly scattering media, such as biological tissue. An advantage of this method is that it does not rely on diffusion theory, thus it is applicable to strongly absorbing media and at small source-detector separations. Monte Carlo simulations and phantom measurements are used to illustrate the achievable accuracy of the system. The method was applied to non-invasive in- vivo tracking of haemoglobin concentration in biological tissue. The results correlated well to clinically determined Hb concentrations.

Citation Download Citation

Rene Alexander Bolt, Johannes Sake Kanger, Frits F. M. de Mul, Xiaomao Wu, Shu-Jen Yeh, and Omar S. Khalil "Noninvasive determination of concentration of compounds in strongly absorbing biological tissue", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382729

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