Anatomic and physiologic factors influencing transcutaneous optical diagnosis of deep-seated lesions

Sharon L. Thomsen M.D.

doi:10.1117/12.305373

16 April 1998 Anatomic and physiologic factors influencing transcutaneous optical diagnosis of deep-seated lesions

Sharon L. Thomsen M.D.

Proceedings Volume 3250, Optical Biopsy II; (1998) https://doi.org/10.1117/12.305373
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Human skin is a formidible light barrier to non-invasive, transcutaneous optical diagnosis of deep-seated lesions. Human skin is composed to two anatomically and physiologically distinct layers, the superficial epidermis and the deeper dermis. Each contains optically active tissue components including scatters, absorber and fluorophores. Beneath the skin is the subcutaneous fibroadipose tissue that varies in thickness and composition depending on the anatomic site and the person's habitus. Delivery of interrogation light and capture of reflected or emitted diagnostic light from deep-seated lesions will be greatly influenced by the skin and subcutaneous tissue. Diagnostic strategies will have to include careful analysis of anatomically distinct 'normal tissues' before 'abnormal lesions' can be distinguished.

Citation Download Citation

Sharon L. Thomsen M.D. "Anatomic and physiologic factors influencing transcutaneous optical diagnosis of deep-seated lesions", Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); https://doi.org/10.1117/12.305373

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available