Quantitative near-infrared spectroscopy on patients with peripheral vascular disease

Maria-Angela Franceschini; Sergio Fantini; Renato Palumbo; Leonella Pasqualini; Gaetano Vaudo; Edoardo Franceschini; Enrico Gratton; Barbara Palumbo; Salvatore Innocente; Elmo Mannarino

doi:10.1117/12.301041

1 January 1998 Quantitative near-infrared spectroscopy on patients with peripheral vascular disease

Maria-Angela Franceschini, Sergio Fantini, Renato Palumbo, Leonella Pasqualini, Gaetano Vaudo, Edoardo Franceschini, Enrico Gratton, Barbara Palumbo, Salvatore Innocente, Elmo Mannarino

Author Affiliations +

Proceedings Volume 3194, Photon Propagation in Tissues III; (1998) https://doi.org/10.1117/12.301041
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

We have used near-infrared spectroscopy to measure the hemoglobin saturation at rest and during exercise on patients affected by peripheral vascular disease (PVD). The instrument used in our study is a frequency-domain tissue oximeter which employs intensity modulated (110 MHz) laser diodes. We examined 9 subjects, 3 of which were controls and 6 were patients affected by stage II PVD. The optical probe was located on the calf muscle of the subjects. The measurement protocol consisted of: (1) baseline (approximately 5 min); (2) stationary bicycle exercise (approximately 5 min); (3) recovery (approximately 15 min). The change in hemoglobin saturation during exercise ((Delta) Y) and the recovery time after exercise (t_rec) were significantly greater in the PVD patients ((Delta) Y equals -21 +/- 3%, t_rec equals 5.9 +/- 3.8 min) than in the control subjects ((Delta) Y equals 2 +/- 3%, t_rec equals 0.6 +/- 0.1 min).

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Maria-Angela Franceschini, Sergio Fantini, Renato Palumbo, Leonella Pasqualini, Gaetano Vaudo, Edoardo Franceschini, Enrico Gratton, Barbara Palumbo, Salvatore Innocente, and Elmo Mannarino "Quantitative near-infrared spectroscopy on patients with peripheral vascular disease", Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); https://doi.org/10.1117/12.301041

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