Simulation and analysis of dynamic brain PET images

Jeffrey T. Yap; Chin-Tu Chen; Malcolm Cooper

doi:10.1117/12.237869

8 April 1996 Simulation and analysis of dynamic brain PET images

Jeffrey T. Yap, Chin-Tu Chen, Malcolm Cooper

Proceedings Volume 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images; (1996) https://doi.org/10.1117/12.237869
Event: Medical Imaging 1996, 1996, Newport Beach, CA, United States

Abstract

We have developed a software package which combines the simulation and analysis of dynamic brain images acquired by positron emission tomography. In the spatial domain, standard digitized phantoms are used to create spatial maps which represent various structures in the brain. In the temporal domain, kinetic models are used to simulate the dynamics at the pixel level for each time-activity curve. Physical characteristics such as spatial resolution and noise are then modeled on individual image frames. This software has been used in the case of [18F]fluorodeoxyglucose studies to produce realistic simulations which were further analyzed to confirm previous findings based on real clinical data.

Citation Download Citation

Jeffrey T. Yap, Chin-Tu Chen, and Malcolm Cooper "Simulation and analysis of dynamic brain PET images", Proc. SPIE 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images, (8 April 1996); https://doi.org/10.1117/12.237869

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