Physical activity mitigates dysfunction of the neuro-vascular unit in a mouse model of Alzheimer’s disease

Alfredo Cardenas-Rivera; Eda K. Erdogmus; Austin Birmingham; Jaime Anton-Arnal; Nazila Loghmani; Chang Liu; Zhengyi Lu; Yuntao Li; Mohammad A. Yaseen

doi:10.1117/12.3002796

12 March 2024 Physical activity mitigates dysfunction of the neuro-vascular unit in a mouse model of Alzheimer’s disease

Alfredo Cardenas-Rivera, Eda K. Erdogmus, Austin Birmingham, Jaime Anton-Arnal, Nazila Loghmani, Chang Liu, Zhengyi Lu, Yuntao Li, Mohammad A. Yaseen

Author Affiliations +

Proceedings Volume 12828, Neural Imaging and Sensing 2024; 128280C (2024) https://doi.org/10.1117/12.3002796
Event: SPIE BiOS, 2024, San Francisco, California, United States

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Abstract

The Neurovascular Unit (NVU) dynamically regulates oxygen supply to satisfy neural metabolic demand. Amyloid-β (Aβ) accumulation and hyperphosphorylated Tau in Alzheimer’s disease (AD) disrupt the NVU. Empirical evidence strongly indicates that physical activity (PA) reduces the rate of cognitive impairment, but the physiological mechanism(s) PA’s neuroprotective benefits remain unclear. We propose PA improves the brain parenchymal oxygenation and reduces metabolic deficits. Using the novel oxygen sensitizer, Oxyphor 2P, and 2-photon phosphorescence lifetime imaging (2P-PLIM), our results indicate that the PA shows the potential to curtail AD progression by increasing microvascular oxygenation and preserving NVU function.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Alfredo Cardenas-Rivera, Eda K. Erdogmus, Austin Birmingham, Jaime Anton-Arnal, Nazila Loghmani, Chang Liu, Zhengyi Lu, Yuntao Li, and Mohammad A. Yaseen "Physical activity mitigates dysfunction of the neuro-vascular unit in a mouse model of Alzheimer’s disease", Proc. SPIE 12828, Neural Imaging and Sensing 2024, 128280C (12 March 2024); https://doi.org/10.1117/12.3002796

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