Effects of laser induced shockwave on neurons from an Alzheimer’s mouse model

Veronica Gomez Godinez; Steven Zheng; Matthew Hsin-De Tran; Chengbiao Wu; Linda Shi

doi:10.1117/12.2677546

5 October 2023 Effects of laser induced shockwave on neurons from an Alzheimer’s mouse model

Veronica Gomez Godinez, Steven Zheng, Matthew Hsin-De Tran, Chengbiao Wu, Linda Shi

Proceedings Volume 12649, Optical Trapping and Optical Micromanipulation XX; 126490U (2023) https://doi.org/10.1117/12.2677546
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States

Conference Poster

Abstract

Neuronal responses to injury are of interest to the development of methods to mitigate damage and stimulate repair. We utilized a single pulse from a 1030nm laser to create a laser induced shockwave (LIS) to subject neuronal cells to injury and compare the effects of injury on neurons from an Alzheimer’s Disease (AD) mouse model and wild type (WT) mice. We found differences in the calcium response to LIS in AD versus WT neurons. Additionally, we found that LIS induced cell death led to a calcium elevation which differed from that in cells that stayed alive. Therefore, the calcium response can be utilized to separate dead cells from live cells.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Veronica Gomez Godinez, Steven Zheng, Matthew Hsin-De Tran, Chengbiao Wu, and Linda Shi "Effects of laser induced shockwave on neurons from an Alzheimer’s mouse model", Proc. SPIE 12649, Optical Trapping and Optical Micromanipulation XX, 126490U (5 October 2023); https://doi.org/10.1117/12.2677546

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