Recording dual-mode near-infrared spectroscopy and ultra-low frequency electroencephalography during spreading depression

Shahbaz Askari; Zoya Bastany; Ali Gorji; Guy Dumont

doi:10.1117/12.2623088

2 March 2022 Recording dual-mode near-infrared spectroscopy and ultra-low frequency electroencephalography during spreading depression

Shahbaz Askari, Zoya Bastany, Ali Gorji, Guy Dumont

Author Affiliations +

Proceedings Volume 11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III; 1195605 (2022) https://doi.org/10.1117/12.2623088
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Spreading depression (SD) is an ultra-slow (30 to 90 seconds) brain electrical activity caused by the high concentration of extracellular potassium ions (K+) and plays an essential role in the pathophysiology of epilepsy. However, the SD signal amplitude is higher than the conventional EEG signal (10 to 300 microvolt). Due to filter effects of the skull and in the presence of other non-neuronal slow shift potentials (like electrode low-frequency shifts and motion artifact) the recording of an SD signal with the non-invasive method can be a difficult task. Near-infrared spectroscopy (NIRS) is wavelength-dependent absorption spectroscopy. Light absorption is a function of the molecular properties of substances within the light path. Hemodynamic variations accompany the propagation of the SD. Thus, using near-infrared spectroscopy besides EEG can provide an additional biomarker to distinguish SD from non-neuronal EEG slow shifts. This study used NIRS/EEG, a dual-modal NIRS and ultra-low frequency (0.01Hz to 80Hz) EEG device to record five Wistar rats (anesthetized). One NIRS source, NIRS detector, and EEG electrode were positioned above the somatosensory neocortex on the depilated skin. The EEG reference electrode was close to the rat’s nasion. The distance between source and detector was 8mm. KCL solution (3 mole/L, 10μl) was injected into the rat neocortex to generate the SD wave, and NIRS/EEG device performed the simultaneous recording. The increase of HHb (deoxyhemoglobin) accompanied by the slow shift of EEG was detected during SD. The rise of THb (Total hemoglobin) was also detected during the induced SD.

Conference Presentation

Citation Download Citation

Shahbaz Askari, Zoya Bastany, Ali Gorji, and Guy Dumont "Recording dual-mode near-infrared spectroscopy and ultra-low frequency electroencephalography during spreading depression", Proc. SPIE 11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III, 1195605 (2 March 2022); https://doi.org/10.1117/12.2623088

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