Estimation of the cross-sectional surface area of the waist of the nerve fiber layer at the optic nerve head

Konstancija Kisonaite; Zhaohua Yu; Faisal Raeme; Simone Bendazzoli; Chunliang Wang; Per G. Söderberg

doi:10.1117/12.2608073

4 March 2022 Estimation of the cross-sectional surface area of the waist of the nerve fiber layer at the optic nerve head

Konstancija Kisonaite, Zhaohua Yu, Faisal Raeme, Simone Bendazzoli, Chunliang Wang, Per G. Söderberg

Author Affiliations +

Proceedings Volume 11941, Ophthalmic Technologies XXXII; 119410F (2022) https://doi.org/10.1117/12.2608073
Event: SPIE BiOS, 2022, San Francisco, California, United States

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Abstract

Glaucoma is a global disease that leads to blindness due to pathological loss of retinal ganglion cell axons in the optic nerve head (ONH). The presented project aims at improving a computational algorithm for estimating the thickness and surface area of the waist of the nerve fiber layer in the ONH. Our currently developed deep learning AI algorithm meets the need for a morphometric parameter that detects glaucomatous change earlier than current clinical follow-up methods. In 3D OCT image volumes, two different AI algorithms identify the Optic nerve head Pigment epithelium Central Limit (OPCL) and the Inner limit of the Retina Closest Point (IRCP) in a 3D grid. Our computational algorithm includes the undulating surface area of the waist of the ONH, as well as waist thickness. In 16 eyes of 16 non-glaucomatous subjects aged [20;30] years, the mean difference in minimal thickness of the waist of the nerve fiber layer between our previous and the current post-processing strategies was estimated as CI_μ(0.95) 0 ±1 μm (D.f. 15). The mean surface area of the waist of the nerve fiber layer in the optic nerve head was 1.97 ± 0.19 mm². Our computational algorithm results in slightly higher values for surface areas compared to published work, but as expected, this may be due to surface undulations of the waist being considered. Estimates of the thickness of the waist of the ONH yields estimates of the same order as our previous computational algorithm.

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Konstancija Kisonaite, Zhaohua Yu, Faisal Raeme, Simone Bendazzoli, Chunliang Wang, and Per G. Söderberg "Estimation of the cross-sectional surface area of the waist of the nerve fiber layer at the optic nerve head", Proc. SPIE 11941, Ophthalmic Technologies XXXII, 119410F (4 March 2022); https://doi.org/10.1117/12.2608073

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