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5 March 2021 Optical-coherence-tomography based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroid
Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Shen, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno
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Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 116550N (2021) https://doi.org/10.1117/12.2576291
Event: SPIE BiOS, 2021, Online Only
Abstract
We present a new non-invasive label-free imaging method, which visualizes tissue dynamics/sub-cellular motion by analyzing the temporal fluctuation of optical coherence tomography (OCT) signals. Our modality has been utilized for visualization and quantification of the time course necrotic process of human breast adenocarcinoma spheroid (MCF7). The response of MCF7 spheroid against anti-cancer drug has also been investigated. The presented method is quantitative. So, the necrotic process was not only shown by images but the dynamics signal value is also plotted as a function of time. It showed clear degradation of tissue activity by time.
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Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Shen, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, and Yoshiaki Yasuno "Optical-coherence-tomography based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroid", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116550N (5 March 2021); https://doi.org/10.1117/12.2576291
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KEYWORDS
Optical coherence tomography
Tissue optics
Tumors
Mode conditioning cables
Visualization
Algorithm development
Visual analytics
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