In vivo quantification of placental hemodynamics with diffuse optical spectroscopy

Lin Wang; Jeffrey M. Cochran; Tiffany Ko; Wesley B. Baker; Kenneth Abramson; David Busch; Lian He; Arjun G. Yodh; Nadav Schwartz

doi:10.1117/12.2583369

5 March 2021 In vivo quantification of placental hemodynamics with diffuse optical spectroscopy

Lin Wang, Jeffrey M. Cochran, Tiffany Ko, Wesley B. Baker, Kenneth Abramson, David Busch, Lian He, Arjun G. Yodh, Nadav Schwartz

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390O (2021) https://doi.org/10.1117/12.2583369
Event: SPIE BiOS, 2021, Online Only

Abstract

Currently, no bedside tool measures placental hemoglobin properties. Thus, we developed a hybrid optical/ultrasound (US) system to measure and study placental oxygen dynamics noninvasively. The system combines a Frequency-Domain Diffuse Optical Spectroscopy (FD-DOS) instrument that is capable of probing tissue as deep as 5 cm below the surface, with a commercial US device to provide synchronized tissue morphological information. Multi-layer models of photon diffusion are then utilized to reconstruct placental hemoglobin properties from FD-DOS data with morphological constraints from US. Phantom experiments, simulations, and studies in human subjects demonstrate that this instrument quantifies in vivo placental hemodynamics non-invasively.

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Lin Wang, Jeffrey M. Cochran, Tiffany Ko, Wesley B. Baker, Kenneth Abramson, David Busch, Lian He, Arjun G. Yodh, and Nadav Schwartz "In vivo quantification of placental hemodynamics with diffuse optical spectroscopy", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390O (5 March 2021); https://doi.org/10.1117/12.2583369

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