Polarization-sensitive OCT with noise bias correction for quantitative, birefringence-based neuroimaging with improved accuracy

Bernhard Baumann; Danielle J. Harper; Pablo Eugui; Johanna Gesperger; Antonia Lichtenegger; Marco Augustin; Conrad W. Merkle; Adelheid Wöhrer

doi:10.1117/12.2577188

5 March 2021 Polarization-sensitive OCT with noise bias correction for quantitative, birefringence-based neuroimaging with improved accuracy

Bernhard Baumann, Danielle J. Harper, Pablo Eugui, Johanna Gesperger, Antonia Lichtenegger, Marco Augustin, Conrad W. Merkle, Adelheid Wöhrer

Author Affiliations +

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116292I (2021) https://doi.org/10.1117/12.2577188
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) provides volumetric tissue imaging based on inherent scattering and polarization properties. In fibrous structures such as white matter tissue, PS-OCT enables quantitative mapping of birefringence. For single-input PS-OCT layouts, the accuracy of birefringence measurements strongly depends on the signal-to-noise ratio (SNR) and is prone to mapping artifacts in case of low SNR. Here we present a simple yet effective approach for improving the accuracy of phase retardation and birefringence measurements by performing a noise bias correction of the detected signal amplitudes. We present simulation data to illustrate the influence of the noise bias correction on phase retardation measurements and support our analysis with real-world PS-OCT image data.

Conference Presentation

Citation Download Citation

Bernhard Baumann, Danielle J. Harper, Pablo Eugui, Johanna Gesperger, Antonia Lichtenegger, Marco Augustin, Conrad W. Merkle, and Adelheid Wöhrer "Polarization-sensitive OCT with noise bias correction for quantitative, birefringence-based neuroimaging with improved accuracy", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116292I (5 March 2021); https://doi.org/10.1117/12.2577188

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