Development of near-infrared fluorophores for use as nerve-specific contrast agents for fluorescence guided surgery

Lei G. Wang; Connor W. Barth; Antonio R. Montaño; Alexander L. Antaris; Jonathan M. Sorger; Summer L. Gibbs

doi:10.1117/12.2583286

8 March 2021 Development of near-infrared fluorophores for use as nerve-specific contrast agents for fluorescence guided surgery

Lei G. Wang, Connor W. Barth, Antonio R. Montaño, Alexander L. Antaris, Jonathan M. Sorger, Summer L. Gibbs

Author Affiliations +

Proceedings Volume 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII; 116250S (2021) https://doi.org/10.1117/12.2583286
Event: SPIE BiOS, 2021, Online Only

Abstract

Fluorescence-guided surgery (FGS) to aid in the precise visualization of vital nerve structures in real-time intraoperatively could greatly improve patient outcomes. We took a medicinal chemistry approach that facilitated the design of our first-in-class NIR nerve-binding small molecule fluorophore libraries with excitation and emission profiles compatible with the “700-” and “800-” nm fluorescence imaging channels in the clinical grade FGS systems. Molecular engineering of the lead candidates allowed for the development of water-soluble nerve-specific contrast agents with improved safety profile that has great potential for clinical translation in the near future.

Conference Presentation

Citation Download Citation

Lei G. Wang, Connor W. Barth, Antonio R. Montaño, Alexander L. Antaris, Jonathan M. Sorger, and Summer L. Gibbs "Development of near-infrared fluorophores for use as nerve-specific contrast agents for fluorescence guided surgery", Proc. SPIE 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII, 116250S (8 March 2021); https://doi.org/10.1117/12.2583286

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