Controlling the embryonic heart beat through optogenetics (Conference Presentation)

Andrew L. Lopez III; Irina V. Larina

doi:10.1117/12.2554349

9 March 2020 Controlling the embryonic heart beat through optogenetics (Conference Presentation)

Andrew L. Lopez III, Irina V. Larina

Proceedings Volume 11239, Dynamics and Fluctuations in Biomedical Photonics XVII; 112390V (2020) https://doi.org/10.1117/12.2554349
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Biomechanical signaling is required during cardiac development. Perturbation of heart biomechanics results in a malformed heart, the primary phenotype found in congenital heart disease. Cardiac progenitor cells are responsible for acquiring all cardiac cell fates, expanding, and organizing into a functional heart. How biomechanical signals govern cardiac progenitor cell behavior to achieve cardiac morphogenesis is unknown. In this work, we will implement optogenetic cardiac pacing as a means to control cardiac biomechanics and determine how altered mechanics affects cardiac progenitor cells.

Conference Presentation

Citation Download Citation

Andrew L. Lopez III and Irina V. Larina "Controlling the embryonic heart beat through optogenetics (Conference Presentation)", Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390V (9 March 2020); https://doi.org/10.1117/12.2554349

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