Enhanced model for predicting femoral fracture toughness in ovariectomized mice using Raman spectroscopy and x-ray imaging (Conference Presentation)

Christine M. Massie; Emma Knapp; Keren Chen; Hani A. Awad; Andrew J. Berger

doi:10.1117/12.2546477

9 March 2020 Enhanced model for predicting femoral fracture toughness in ovariectomized mice using Raman spectroscopy and x-ray imaging (Conference Presentation)

Christine M. Massie, Emma Knapp, Keren Chen, Hani A. Awad, Andrew J. Berger

Author Affiliations +

Proceedings Volume 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry; 112360U (2020) https://doi.org/10.1117/12.2546477
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Fracture toughness, a bone’s resistance to breaking, is typically measured via invasive mechanical tests. In this ex vivo study on mouse femurs, four Raman spectral features associated with bone properties were significantly correlated to fracture toughness using a partial least squares regression model. By including parameters measured from dual-energy absorptiometry and micro-computed tomography in the model, fracture toughness predictions on ovariectomized mice were significantly lower than a control cohort’s. This shows that meaningful estimates of fracture toughness can be estimated using input parameters obtained non-destructively.

Conference Presentation

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Christine M. Massie, Emma Knapp, Keren Chen, Hani A. Awad, and Andrew J. Berger "Enhanced model for predicting femoral fracture toughness in ovariectomized mice using Raman spectroscopy and x-ray imaging (Conference Presentation)", Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 112360U (9 March 2020); https://doi.org/10.1117/12.2546477

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KEYWORDS

Raman spectroscopy

Bone

X-ray imaging

Carbonates

Dual energy x-ray absorptiometry

Remote sensing

Minerals

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