Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)

Joy Willemse; Reinier Wener; Fabio Feroldi; Margherita Vaselli; Maximilian G. O. Graefe; Johannes F. de Boer

doi:10.1117/12.2548916

9 March 2020 Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)

Joy Willemse, Reinier Wener, Fabio Feroldi, Margherita Vaselli, Maximilian G. O. Graefe, Johannes F. de Boer

Author Affiliations +

Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 1122811 (2020) https://doi.org/10.1117/12.2548916
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) has been used to extract polarization properties of four different diseased lungs ex vivo, including fibrotic sarcoidosis (FS), chronic obstructive pulmonary disease (COPD), fibrotic extrinsic allergic alveolitis (fibrotic EAA) and cystic fibrosis (CF). An increase in alveoli size has been observed in COPD lungs. Furthermore, an increase in birefringence signal was observed for FS and fibrotic EAA. In CF, a few areas with thick patches of birefringence occurred. The results show potential of in vivo assessment of lung fibrosis. Histology slides of all lungs were acquired, and will be used to further interpret the results.

Conference Presentation

Citation Download Citation

Joy Willemse, Reinier Wener, Fabio Feroldi, Margherita Vaselli, Maximilian G. O. Graefe, and Johannes F. de Boer "Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122811 (9 March 2020); https://doi.org/10.1117/12.2548916

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