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9 March 2020 The optical property and morphometry of human cerebellum cortex with automatic serial sectioning polarization sensitive optical coherence tomography (Conference Presentation)
Hui Wang, Viviana Siless, Morgan Fogarty, Iman Aganj, Douglas Greve, Bruce Fischl
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Proceedings Volume 11226, Neural Imaging and Sensing 2020; 112260R (2020) https://doi.org/10.1117/12.2550620
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Automatic serial sectioning polarization sensitive optical coherence tomography (as-PSOCT) enables volumetric reconstruction of human brain samples with unprecedented resolution and volume coverage. Here we show the laminar structures and the optical properties in human cerebellar cortex using as-PSOCT. The cerebellum cortex was segmented based on the retardance images. The scattering coefficient maps were created, and the thickness maps were generated for the molecular and granular layers, respectively. The relationship between the optical property and the geometry was investigated. The optical property indicated a homogenous cell density despite great variations in the thickness due to the folding patterns in the cerebellum.
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Hui Wang, Viviana Siless, Morgan Fogarty, Iman Aganj, Douglas Greve, and Bruce Fischl "The optical property and morphometry of human cerebellum cortex with automatic serial sectioning polarization sensitive optical coherence tomography (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260R (9 March 2020); https://doi.org/10.1117/12.2550620
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KEYWORDS
Cerebellum
Optical properties
Optical coherence tomography
Polarization
Brain
Image segmentation
Scattering
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