Optoelectronical method for identification of meldonium in urine samples

Bogdan Berghes; Jeni-Carla Colev; Mihai Radu; Mihai Ionică; Georgeta Marcela Bican

doi:10.1117/12.2323816

31 December 2018 Optoelectronical method for identification of meldonium in urine samples

Bogdan Berghes, Jeni-Carla Colev, Mihai Radu, Mihai Ionică, Georgeta Marcela Bican

Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 109773X (2018) https://doi.org/10.1117/12.2323816
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

Meldonium is an anti-ischemia drug developed in 1970 by Ivars Kalvins at the USSR Latvia Institute of organic synthesis. Meldonium is reportedly capable of providing clinical benefit for those suffering from heart conditions, such as low blood flow to the heart and angina, as well as neurodegenerative disorders and bronchopulmonary diseases. It appears that the medical utility of meldonium derives mostly from its ability to modulate cellular energy metabolism¹. This may be due to the drug lowering the consumption of fatty acids, while increasing utilization of carbohydrates for the production of energy. In short, meldonium is advertised as an energy-efficiency catalyst. Since 1 January 2016, it has been on the World Anti-Doping Agency (WADA) list of substances banned from use by athletes. In this work a screening and a confirmation method for Meldonium from urine were developed and validated on LC-MS/MS triple quadrupole (liquid chromatography coupled with mass spectrometry ) (ABSciex QTrap 5500). The validation parameters evaluated were limit of detection, matrix effects, identification criteria, specificity, carry-over and extraction recovery. The evaluated parameters are in accordance with WADA technical documents, both methods being applicable for doping control application.

Citation Download Citation

Bogdan Berghes, Jeni-Carla Colev, Mihai Radu, Mihai Ionică, and Georgeta Marcela Bican "Optoelectronical method for identification of meldonium in urine samples", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773X (31 December 2018); https://doi.org/10.1117/12.2323816

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