Toward handheld real time frequency domain diffuse optical spectroscopy

Vincent J. Kitsmiller; Roy A. Stillwell; Thomas D. O'Sullivan

doi:10.1117/12.2508911

1 March 2019 Toward handheld real time frequency domain diffuse optical spectroscopy

Vincent J. Kitsmiller, Roy A. Stillwell, Thomas D. O'Sullivan

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 1087405 (2019) https://doi.org/10.1117/12.2508911
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Frequency domain diffuse optical spectroscopy (fd-DOS) uses modulated laser light to image tissue and extract quantitative chromophore information. Currently no fd-DOS systems are completely handheld and only one is capable of displaying chromophore data in real time, which could allow for real-time studies of tissue hemodynamics, spatial chromophore (e.g. water, lipid, and hemoglobin) concentrations, greater ease of use by clinicians, and more generally, a simple platform for quantitative tissue spectroscopy. We present progress towards a handheld, real time fd-DOS system based upon an all-digital FPGA coupled hardware approach that includes data collection and processing and can attain imaging speeds of >30Hz. Quantitative optical scattering and absorption measurements are found to be within 10% agreement as compared to a reference system. We conclude that high speed quantitative tissue chromophore assessments are possible with this system-on-a-chip fd-DOS approach, which will enable real time handheld monitoring of rapid physiological changes.

Citation Download Citation

Vincent J. Kitsmiller, Roy A. Stillwell, and Thomas D. O'Sullivan "Toward handheld real time frequency domain diffuse optical spectroscopy", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 1087405 (1 March 2019); https://doi.org/10.1117/12.2508911

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