Examination of corticothalamic fiber projections in United States service members with mild traumatic brain injury

Faisal M. Rashid; Emily L. Dennis; Julio E. Villalon-Reina; Yan Jin; Jeffrey D. Lewis; Gerald E. York; Paul M. Thompson; David F. Tate

doi:10.1117/12.2284569

17 November 2017 Examination of corticothalamic fiber projections in United States service members with mild traumatic brain injury

Faisal M. Rashid, Emily L. Dennis, Julio E. Villalon-Reina, Yan Jin, Jeffrey D. Lewis, Gerald E. York, Paul M. Thompson, David F. Tate

Author Affiliations +

Proceedings Volume 10572, 13th International Conference on Medical Information Processing and Analysis; 105720D (2017) https://doi.org/10.1117/12.2284569
Event: 13th International Symposium on Medical Information Processing and Analysis, 2017, San Andres Island, Colombia

Abstract

Mild traumatic brain injury (mTBI) is characterized clinically by a closed head injury involving differential or rotational movement of the brain inside the skull. Over 3 million mTBIs occur annually in the United States alone. Many of the individuals who sustain an mTBI go on to recover fully, but around 20% experience persistent symptoms. These symptoms often last for many weeks to several months. The thalamus, a structure known to serve as a global networking or relay system for the rest of the brain, may play a critical role in neurorehabiliation and its integrity and connectivity after injury may also affect cognitive outcomes. To examine the thalamus, conventional tractography methods to map corticothalamic pathways with diffusion-weighted MRI (DWI) lead to sparse reconstructions that may contain false positive fibers that are anatomically inaccurate. Using a specialized method to zero in on corticothalamic pathways with greater robustness, we noninvasively examined corticothalamic fiber projections using DWI, in 68 service members. We found significantly lower fractional anisotropy (FA), a measure of white matter microstructural integrity, in pathways projecting to the left pre- and postcentral gyri – consistent with sensorimotor deficits often found post-mTBI. Mapping of neural circuitry in mTBI may help to further our understanding of mechanisms underlying recovery post-TBI.

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Faisal M. Rashid, Emily L. Dennis, Julio E. Villalon-Reina, Yan Jin, Jeffrey D. Lewis, Gerald E. York, Paul M. Thompson, and David F. Tate "Examination of corticothalamic fiber projections in United States service members with mild traumatic brain injury", Proc. SPIE 10572, 13th International Conference on Medical Information Processing and Analysis, 105720D (17 November 2017); https://doi.org/10.1117/12.2284569

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KEYWORDS

Diffusion weighted imaging

Thalamus

Traumatic brain injury

Brain

Injuries

Magnetic resonance imaging

Head

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