Multi-modal spectroscopic imaging with synchrotron light to study mechanisms of brain disease

Kelly L. Summers; Nicholas Fimognari; Ashley Hollings; Mitchell Kiernan; Virginie Lam; Rebecca J. Tidy; Ryu Takechi; Graham N. George; Ingrid J. Pickering; John C. Mamo; Hugh H. Harris; Mark J. Hackett

doi:10.1117/12.2272365

29 April 2017 Multi-modal spectroscopic imaging with synchrotron light to study mechanisms of brain disease

Kelly L. Summers, Nicholas Fimognari, Ashley Hollings, Mitchell Kiernan, Virginie Lam, Rebecca J. Tidy, Ryu Takechi, Graham N. George, Ingrid J. Pickering, John C. Mamo, Hugh H. Harris, Mark J. Hackett

Author Affiliations +

Proceedings Volume 10340, International Conference on Biophotonics V; 1034002 (2017) https://doi.org/10.1117/12.2272365
Event: International Conference on Biophotonics V, 2017, Perth, Australia

Abstract

The international health care costs associated with Alzheimer’s disease (AD) and dementia have been predicted to reach $2 trillion USD by 2030. As such, there is urgent need to develop new treatments and diagnostic methods to stem an international health crisis. A major limitation to therapy and diagnostic development is the lack of complete understanding about the disease mechanisms. Spectroscopic methods at synchrotron light sources, such as FTIR, XRF, and XAS, offer a “multi-modal imaging platform” to reveal a wealth of important biochemical information in situ within ex vivo tissue sections, to increase our understanding of disease mechanisms.

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Kelly L. Summers, Nicholas Fimognari, Ashley Hollings, Mitchell Kiernan, Virginie Lam, Rebecca J. Tidy, Ryu Takechi, Graham N. George, Ingrid J. Pickering, John C. Mamo, Hugh H. Harris, and Mark J. Hackett "Multi-modal spectroscopic imaging with synchrotron light to study mechanisms of brain disease", Proc. SPIE 10340, International Conference on Biophotonics V, 1034002 (29 April 2017); https://doi.org/10.1117/12.2272365

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