Development of ex vivo model for determining temperature distribution in tumor tissue during photothermal therapy

Shaojie Liu; Austin Doughty; Sana Mesiya; Alex Pettitt; Feifan Zhou; Wei R. Chen

doi:10.1117/12.2250421

20 February 2017 Development of ex vivo model for determining temperature distribution in tumor tissue during photothermal therapy

Shaojie Liu, Austin Doughty, Sana Mesiya, Alex Pettitt, Feifan Zhou, Wei R. Chen

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Proceedings Volume 10065, Biophotonics and Immune Responses XII; 100650Q (2017) https://doi.org/10.1117/12.2250421
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Temperature distribution in tissue is a crucial factor in determining the outcome of photothermal therapy in cancer treatment. In order to investigate the temperature distribution in tumor tissue during laser irradiation, we developed a novel ex vivo device to simulate the photothermal therapy on tumors. A 35°C, a thermostatic incubator was used to provide a simulation environment for body temperature of live animals. Different biological tissues (chicken breast and bovine liver) were buried inside a tissue-simulating gel and considered as tumor tissues. An 805-nm laser was used to irradiate the target tissue. A fiber with an interstitial cylindrical diffuser (10 mm) was directly inserted in the center of the tissue, and the needle probes of a thermocouple were inserted into the tissue paralleling the laser fiber at different distances to measure the temperature distribution. All of the procedures were performed in the incubator. Based on the results of this study, the temperature distribution in bovine liver is similar to that of tumor tissue under photothermal therapy with the same doses. Therefore, the developed model using bovine liver for determining temperature distribution can be used during interstitial photothermal therapy.

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Shaojie Liu, Austin Doughty, Sana Mesiya, Alex Pettitt, Feifan Zhou, and Wei R. Chen "Development of ex vivo model for determining temperature distribution in tumor tissue during photothermal therapy", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 100650Q (20 February 2017); https://doi.org/10.1117/12.2250421

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KEYWORDS

Tumors

Tissues

Liver

Laser tissue interaction

Breast

Fiber lasers

Tissue optics

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