Photothermal therapy combined with dinitrophenyl hapten for the treatment of late stage malignant melanoma

Xiaosong Li; Nan Du; Haijun Li; Shan Long; Dianjun Chen; Feifan Zhou; Yuanyuan Xu; Fuli Wang; Wei R. Chen

doi:10.1117/12.2251090

20 February 2017 Photothermal therapy combined with dinitrophenyl hapten for the treatment of late stage malignant melanoma

Xiaosong Li, Nan Du, Haijun Li, Shan Long, Dianjun Chen, Feifan Zhou, Yuanyuan Xu, Fuli Wang, Wei R. Chen

Author Affiliations +

Proceedings Volume 10065, Biophotonics and Immune Responses XII; 1006505 (2017) https://doi.org/10.1117/12.2251090
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

To evaluate the efficacy and safety of photothermal with dinitrophenyl hapten (DNP) for patients with malignant melanoma (MM), Patients with pathology confirmed stage III or IV MM were enrolled. Seventy-two patients were randomized into two groups, DNP alone group (n=36) and DNP plus photothermal therapy group (n=36). The results showed that the patients in the combination treatment group had longer median progression-free survival time (19.0m vs. 12.0m, p=0.007). No severe adverse events were observed in both groups. Thus, the combination of photothermal therapy and DNP maybe a new therapeutic strategy for patients with advanced MM.

Citation Download Citation

Xiaosong Li, Nan Du, Haijun Li, Shan Long, Dianjun Chen, Feifan Zhou, Yuanyuan Xu, Fuli Wang, and Wei R. Chen "Photothermal therapy combined with dinitrophenyl hapten for the treatment of late stage malignant melanoma", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 1006505 (20 February 2017); https://doi.org/10.1117/12.2251090

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