Novel Raman spectroscopy fiber optics system design can enable real-time intraoperative tissue probing for focal cortical dysplasia in children

Hugo Le Moël; Trang Tran; Sandryne David; Guillaume Sheehy; Roy Dudley; Frédéric Leblond

doi:10.1117/12.3001084

13 March 2024 Novel Raman spectroscopy fiber optics system design can enable real-time intraoperative tissue probing for focal cortical dysplasia in children

Hugo Le Moël, Trang Tran, Sandryne David, Guillaume Sheehy, Roy Dudley, Frédéric Leblond

Author Affiliations +

Proceedings Volume PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII; PC1283105 (2024) https://doi.org/10.1117/12.3001084
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In this study, we investigated the use of single-point Raman spectroscopy (RS) to differentiate between normal brain tissue and focal cortical dysplasia (FCD) during epilepsy surgery. Initial RS measurements showed high background noise, but using a different Raman probe with fewer optic fibers, we were able to detect characteristic brain spectra bands in three patients. These bands confirmed the optical signature of normal brain tissue. While statistical significance was not achieved due to the limited number of patients, our study improved the technical methodology for processing brain signals and holds promise for intraoperative detection of FCD in epilepsy surgeries. Further research is needed to validate these findings and enhance surgical outcomes.

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Citation Download Citation

Hugo Le Moël, Trang Tran, Sandryne David, Guillaume Sheehy, Roy Dudley, and Frédéric Leblond "Novel Raman spectroscopy fiber optics system design can enable real-time intraoperative tissue probing for focal cortical dysplasia in children", Proc. SPIE PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, PC1283105 (13 March 2024); https://doi.org/10.1117/12.3001084

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