Multi-agent, near infrared fluorophore reporters to optimize tissue identification in soft tissue sarcoma

Kendra A. Hebert; Kelsey R. Plona; Samuel S. Streeter; William Eward; Eric R. Henderson; Kimberley Samkoe

doi:10.1117/12.3002746

13 March 2024 Multi-agent, near infrared fluorophore reporters to optimize tissue identification in soft tissue sarcoma

Kendra A. Hebert, Kelsey R. Plona, Samuel S. Streeter, William Eward, Eric R. Henderson, Kimberley Samkoe

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250H (2024) https://doi.org/10.1117/12.3002746
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Fluorescence-guided surgery offers strong promise for improving surgical resection of soft-tissue sarcomas (STSs). However, our preclinical and clinical work shows no single reporter fluoresces all areas of the tumor, thereby compromising our ability to reliably detect residual cancer left behind after initial resection. In this work, we develop an innovative strategy for identifying residual tumor following sarcoma removal by optimizing tumor distribution and contrast using multiple near-infrared fluorophore reporters, all with similar emission wavelengths, simultaneously in complementary combinations and test it in a murine xenograft model of STS.

Conference Presentation

Citation Download Citation

Kendra A. Hebert, Kelsey R. Plona, Samuel S. Streeter, William Eward, Eric R. Henderson, and Kimberley Samkoe "Multi-agent, near infrared fluorophore reporters to optimize tissue identification in soft tissue sarcoma", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250H (13 March 2024); https://doi.org/10.1117/12.3002746

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available