Improving brain sensitivity of diffuse correlation spectroscopy blood flow measurements with a three-layer model (Conference Presentation)

Hongting Zhao; Erin Buckley

doi:10.1117/12.2647910

16 March 2023 Improving brain sensitivity of diffuse correlation spectroscopy blood flow measurements with a three-layer model (Conference Presentation)

Hongting Zhao, Erin Buckley

Author Affiliations +

Proceedings Volume PC12393, Biomedical Applications of Light Scattering XIII; PC123930D (2023) https://doi.org/10.1117/12.2647910
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We show that the estimation of cerebral blood flow (CBF) measured with diffuse correlation spectroscopy using a 3-layer model of the head is strongly influenced by errors in assumed values of numerous parameters, including brain optical properties, layer thickness, and head curvature, which are often not known/measured in the clinical setting. However, these parameters (with the exception of layer thickness) have negligible influence on relative changes in CBF (rCBF). Brief pressure modulation can be used to optimize thickness and improve accuracy of rCBF. These findings suggest that the 3-layer model is superior approach to monitor trends in CBF with DCS.

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Hongting Zhao and Erin Buckley "Improving brain sensitivity of diffuse correlation spectroscopy blood flow measurements with a three-layer model (Conference Presentation)", Proc. SPIE PC12393, Biomedical Applications of Light Scattering XIII, PC123930D (16 March 2023); https://doi.org/10.1117/12.2647910

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KEYWORDS

Brain

Spectroscopy

Blood circulation

Signal to noise ratio

Head

Cerebral blood flow

Data modeling

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