Characterisation and quantification of the limbal architecture and biomechanical properties using optical coherence tomography or elastography (Conference Presentation)

Ryan Dimmock; Yilong Zhang; Gibran Butt; Zhihong Huang; Saeeha Rauz; Ying Yang

doi:10.1117/12.2650277

16 March 2023 Characterisation and quantification of the limbal architecture and biomechanical properties using optical coherence tomography or elastography (Conference Presentation)

Ryan Dimmock, Yilong Zhang, Gibran Butt, Zhihong Huang, Saeeha Rauz, Ying Yang

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Proceedings Volume PC12393, Biomedical Applications of Light Scattering XIII; PC1239304 (2023) https://doi.org/10.1117/12.2650277
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

In the present study, for the first time, spectral-domain optical coherence tomography (SD-OCT) and optical coherence elastography (OCE) have been used in a combinatorial manner to characterise the corneal limbal architecture and biomechanical properties. 11 cadaveric corneas were obtained from a UK tissue bank. The architecture and effect of donor age on the limbal Palisades of were quantified using SD-OCT. OCE was used to determine the Young’s modulus of the epithelium and POV regions. The regional stiffness differences were observed, with ageing effect. Hence a correlation of structural and biomechanical properties within the limbal niche was demonstrated.

Conference Presentation

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Ryan Dimmock, Yilong Zhang, Gibran Butt, Zhihong Huang, Saeeha Rauz, and Ying Yang "Characterisation and quantification of the limbal architecture and biomechanical properties using optical coherence tomography or elastography (Conference Presentation)", Proc. SPIE PC12393, Biomedical Applications of Light Scattering XIII, PC1239304 (16 March 2023); https://doi.org/10.1117/12.2650277

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KEYWORDS

Optical coherence tomography

Elastography

Tissue optics

Tissues

Coherence (optics)

Cornea

Statistical analysis

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