Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald

Differences in orientation tuning between pinwheel and domain neurons in primary visual cortex depend on contrast and size

[+] Author Affiliations
Yong-Jun Liu

University of California Irvine, School of Medicine, Department of Anatomy and Neurobiology, Irvine, California, United States

Chinese Academy of Agricultural Sciences, Institute of Apicultural Research, Department of Honeybee Protection and Biosafety, Beijing, China

Maziar Hashemi-Nezhad

University of California Irvine, School of Medicine, Department of Anatomy and Neurobiology, Irvine, California, United States

Technical University Berlin, Neuroinformatics Group, Department of Software Engineering and Theoretical Computer Science, Administrative Office MAR 5-6, Marchstraße, Berlin, Germany

Bernstein Center for Computational Neuroscience, Berlin, Germany

David C. Lyon

University of California Irvine, School of Medicine, Department of Anatomy and Neurobiology, Irvine, California, United States

Neurophoton. 4(3), 031209 (May 13, 2017). doi:10.1117/1.NPh.4.3.031209
History: Received December 5, 2016; Accepted April 24, 2017
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Abstract.  Intrinsic signal optical imaging reveals a highly modular map of orientation preference in the primary visual cortex (V1) of several species. This orientation map is characterized by domains and pinwheels where local circuitry is either more or less orientation selective, respectively. It has now been repeatedly demonstrated that neurons in pinwheels tend to be more broadly tuned to orientation, likely due to the broad range of orientation preference of the neighboring neurons forming pinwheels. However, certain stimulus conditions, such as a decrease in contrast or an increase in size, significantly sharpen tuning widths of V1 neurons. Here, we find that pinwheel neuron tuning widths are broader than domain neurons only for high contrast, optimally sized stimuli, conditions that maximize excitation through feedforward, and local cortical processing. When contrast was lowered or size increased, orientation tuning width sharpened and became equal. These latter conditions are conducive to less local excitation either through lower feedforward drive or by surround suppression arising from long-range cortical circuits. Tuning width differences between pinwheel and domain neurons likely arise through more local circuitry and are overcome through recruitment of longer-range cortical circuits.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Topics

Nerve ; Visual cortex

Citation

Yong-Jun Liu ; Maziar Hashemi-Nezhad and David C. Lyon
"Differences in orientation tuning between pinwheel and domain neurons in primary visual cortex depend on contrast and size", Neurophoton. 4(3), 031209 (May 13, 2017). ; http://dx.doi.org/10.1117/1.NPh.4.3.031209


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