Special Section on Functional Near Infrared Spectroscopy, Part 1

Relationship between relative cerebral blood flow, relative cerebral blood volume, and relative cerebral metabolic rate of oxygen in the preterm neonatal brain

[+] Author Affiliations
Mina Nourhashemi, Guy Kongolo, Mahdi Mahmoudzadeh, Sabrina Goudjil

Université de Picardie, INSERM U 1105, GRAMFC, CHU Sud, rue René Laennec, 80054 Amiens Cedex 1, France

Neurophoton. 4(2), 021104 (Apr 18, 2017). doi:10.1117/1.NPh.4.2.021104
History: Received January 13, 2017; Accepted March 30, 2017
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Abstract.  The mechanisms responsible for coupling between relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative cerebral metabolic rate of oxygen (rCMRO2), an important function of the microcirculation in preterm infants, remain unclear. Identification of a causal relationship between rCBF–rCBV and rCBFrCMRO2 in preterms may, therefore, help to elucidate the principles of cortical hemodynamics during development. We simultaneously recorded rCBF and rCBV and estimated rCMRO2 by two independent acquisition systems: diffuse correlation spectroscopy and near-infrared spectroscopy, respectively, in 10 preterms aged between 28 and 35 weeks of gestational age. Transfer entropy was calculated in order to determine the directionality between rCBF–rCBV and rCBFrCMRO2. The surrogate method was applied to determine statistical significance. The results show that rCBV and rCMRO2 have a predominant driving influence on rCBF at the resting state in the preterm neonatal brain. Statistical analysis robustly detected the correct directionality of rCBV on rCBF and rCMRO2 on rCBF. This study helps to clarify the early organization of the rCBV–rCBF and rCBFrCMRO2 inter-relationship in the immature cortex.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Mina Nourhashemi ; Guy Kongolo ; Mahdi Mahmoudzadeh ; Sabrina Goudjil and Fabrice Wallois
"Relationship between relative cerebral blood flow, relative cerebral blood volume, and relative cerebral metabolic rate of oxygen in the preterm neonatal brain", Neurophoton. 4(2), 021104 (Apr 18, 2017). ; http://dx.doi.org/10.1117/1.NPh.4.2.021104


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