Neurophotonics Letters

Spatial landscape of oxygen in and around microvasculature during epileptic events

[+] Author Affiliations
Cong Zhang, Mohammad Moeini, Frédéric Lesage

École Polytechnique de Montréal, Department of Electrical Engineering, Montreal, Quebec, Canada

Montreal Heart Institute, Montreal, Quebec, Canada

Neurophoton. 4(1), 010501 (Mar 11, 2017). doi:10.1117/1.NPh.4.1.010501
History: Received October 31, 2016; Accepted February 17, 2017
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Abstract.  Measuring changes in cerebral oxygen in tissue microdomains during epilepsy is important to identify hypoxic potential. Here, using a custom-built two-photon microscopy system, we present microscopic measurements of oxygen partial pressure (PO2) in cortical microvessels and tissue of anesthetized mice during 4-aminopyridine (4-AP)-induced epileptic seizures. Investigating epileptic events, we characterized the distribution of the “initial dip” in PO2 in arterioles, venules, and tissue near the 4-AP injection site. Our results reveal a correlation between the percent change in PO2 during the “initial dip” and the diameter of nearest arterioles and venules.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Topics

Oxygen ; Tissues

Citation

Cong Zhang ; Mohammad Moeini and Frédéric Lesage
"Spatial landscape of oxygen in and around microvasculature during epileptic events", Neurophoton. 4(1), 010501 (Mar 11, 2017). ; http://dx.doi.org/10.1117/1.NPh.4.1.010501


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