Special Section on Brain Mapping and Therapeutics

Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence

[+] Author Affiliations
Zheng Huang, Jian Zou

Fujian Normal University, MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, 8 Shangsan Road, Fuzhou 350007, China

Songsheng Shi

Fujian Medical University, Union Hospital, Department of Neurosurgery, 29 Xinquan Road, Fuzhou 350001, China

Haixia Qiu

Chinese PLA General Hospital, Department of Laser Medicine, 28 Fuxing Road, Beijing 100039, China

Desheng Li

Affiliated Hospital of Academy of Military Medical Sciences, Department of Neurosurgery, 8 Dongda Avenue, Beijing 100071, China

Shaoshan Hu

The Second Affiliated Hospital of Harbin Medical University, Department of Neurosurgery, 246 Xuefu Road, Harbin 150001, China

Neurophoton. 4(1), 011011 (Jan 12, 2017). doi:10.1117/1.NPh.4.1.011011
History: Received July 1, 2016; Accepted December 20, 2016
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Abstract.  Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Zheng Huang ; Songsheng Shi ; Haixia Qiu ; Desheng Li ; Jian Zou, et al.
"Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence", Neurophoton. 4(1), 011011 (Jan 12, 2017). ; http://dx.doi.org/10.1117/1.NPh.4.1.011011


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