In recent years, a variety of studies have been conducted using neuroimaging tools to develop a better understanding of complex neurological process and phenomena underlying pain. Several fMRI-based studies have revealed possible interrelationships between pain and brain functions noninvasively. In particular, Kong et al. reported significant activations (i.e., BOLD signal increase from baseline) in several cortical and subcortical regions during high-pain thermal stimulation over the right forearm of a group of controls using fMRI. Some of the activated regions reported included, but were not limited to, the prefrontal (BAs 9, 10, 44, 46) and somatosensory cortices (i.e., S1 and S2 regions).44 Another recent fMRI study also reported significant activations in several cortical and subcortical regions when a high-pain cold stimulus was applied to the thenar surface of the right hand. The activated regions included, but were not limited to, the bilateral anterior insula, bilateral dorsal ACC extending into the presupplementary motor area (BAs 6, 8, 24, 32), and the right lateral PFC (i.e., DLPFC and VLPFC; BAs 9, 10, 44, 45, 46, 47).45 In this study, our results also present similar activations in several prefrontal cortical areas (such as BAs 8, 9, 10, 44, 45, and 46) during high-pain thermal stimulation given at different body sites [see Figs. 6 and 7]. These consistent HPS-evoked activations within the PFC might suggest its critical role in the cognitive evaluation of noxious stimuli. However, this interpretation or expectation needs to be further confirmed by quantitatively correlating hemodynamic responses (i.e., ) with different levels of noxious stimuli (which was not available in this study).