Special Section on Clinical Near-Infrared Spectroscopy and Imaging of the Brain

Near-infrared measurements of brain oxygenation in stroke

[+] Author Affiliations
François Moreau

Université de Sherbrooke, Department of Medicine, CHUS-Hôpital Fleurimont 3001, 12e Avenue Nord, bureau 6501, Québec, Sherbrooke J1H 5N4, Canada

Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada

Runze Yang

University of Calgary, Department of Radiology, Foothills Medical Centre, Room 812, North Tower, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada

University of Calgary, Hotchkiss Brain Institute, Health Research Innovation Centre, Room 1A10, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada

Vivek Nambiar

Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada

Amrita Institute Medical Sciences, Department of Neurology, Center of Neurosciences, Ponekkara, Kochi 682041, India

Andrew M. Demchuk

Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada

University of Calgary, Hotchkiss Brain Institute, Health Research Innovation Centre, Room 1A10, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada

Jeff F. Dunn

University of Calgary, Department of Radiology, Foothills Medical Centre, Room 812, North Tower, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada

University of Calgary, Hotchkiss Brain Institute, Health Research Innovation Centre, Room 1A10, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada

University of Calgary, Experimental Imaging Center, TRW building, Basement level P2, Foothills Medical Centre, 1403-29th Street NW Calgary, Alberta T2N 2T9, Canada

Neurophoton. 3(3), 031403 (Feb 11, 2016). doi:10.1117/1.NPh.3.3.031403
History: Received May 1, 2015; Accepted January 13, 2016
Text Size: A A A

Abstract.  We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS® fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and StO2 in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. StO2 values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced StO2 on the stroke side compared to the contralateral side. The evolution of tHb and StO2 at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

François Moreau ; Runze Yang ; Vivek Nambiar ; Andrew M. Demchuk and Jeff F. Dunn
"Near-infrared measurements of brain oxygenation in stroke", Neurophoton. 3(3), 031403 (Feb 11, 2016). ; http://dx.doi.org/10.1117/1.NPh.3.3.031403


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.