Research Papers

Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping

[+] Author Affiliations
Lia Maria Hocke

McLean Hospital, McLean Imaging Center, 115 Mill Street, Belmont, Massachusetts 02478, United States

Tufts University, Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States

Kenroy Cayetano, Yunjie Tong, Blaise Frederick

McLean Hospital, McLean Imaging Center, 115 Mill Street, Belmont, Massachusetts 02478, United States

Harvard Medical School, Department of Psychiatry, 25 Shattuck Street, Boston, Massachusetts 02115, United States

Neurophoton. 2(4), 045004 (Dec 10, 2015). doi:10.1117/1.NPh.2.4.045004
History: Received June 3, 2015; Accepted October 29, 2015
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Abstract.  Functional near-infrared spectroscopy (fNIRS) is an increasingly important noninvasive method in neuroscience due to its high temporal resolution and ability to independently measure oxy- and deoxy-hemoglobin. However, the relatively low spatial resolution of fNIRS makes it difficult to relate this signal to underlying anatomy. Simultaneous functional magnetic resonance imaging (fMRI) can complement fNIRS with superior spatial resolution and the ability to image the entire brain, providing additional information to improve fNIRS localization. However, current simultaneous fMRI/fNIRS acquisition methods are not optimal, due to the poor physical compatibility of existing MR coils and fNIRS optodes. Here, we present a technique to manufacture a true multimodal fMRI/fNIRS probe in which both modalities can be used with maximal sensitivity. To achieve this, we designed custom MR coils with integral fNIRS optodes using three-dimensional printing. This multimodal probe can be used to optimize spatial (1.2×1.2×1.8mm) and temporal resolution (2.5 Hz) of fMRI, and it provides maximal MRI sensitivity, while allowing for high flexibility in the location and density of fNIRS optodes within the area of interest. Phantom and human data are shown to confirm the improvement in sensitivity in both modalities. This probe shows promise for addressing fundamental questions of the relation of fNIRS to physiology.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Lia Maria Hocke ; Kenroy Cayetano ; Yunjie Tong and Blaise Frederick
"Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping", Neurophoton. 2(4), 045004 (Dec 10, 2015). ; http://dx.doi.org/10.1117/1.NPh.2.4.045004


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