Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses

Meryem A. Yücel; Juliette Selb; Christopher M. Aasted; Mike P. Petkov; Lino Becerra; David Borsook; David A. Boas

doi:10.1117/1.NPh.2.3.035005

11 September 2015 Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses

Meryem A. Yücel, Juliette Selb, Christopher M. Aasted, Mike P. Petkov, Lino Becerra, David Borsook, David A. Boas

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Neurophotonics, Vol. 2, Issue 3, 035005 (September 2015). https://doi.org/10.1117/1.NPh.2.3.035005

Abstract

Autonomic nervous system response is known to be highly task-dependent. The sensitivity of near-infrared spectroscopy (NIRS) measurements to superficial layers, particularly to the scalp, makes it highly susceptible to systemic physiological changes. Thus, one critical step in NIRS data processing is to remove the contribution of superficial layers to the NIRS signal and to obtain the actual brain response. This can be achieved using short separation channels that are sensitive only to the hemodynamics in the scalp. We investigated the contribution of hemodynamic fluctuations due to autonomous nervous system activation during various tasks. Our results provide clear demonstrations of the critical role of using short separation channels in NIRS measurements to disentangle differing autonomic responses from the brain activation signal of interest.

Yücel, Selb, Aasted, Petkov, Becerra, Borsook, and Boas: Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses

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Meryem A. Yücel, Juliette Selb, Christopher M. Aasted, Mike P. Petkov, Lino Becerra, David Borsook, and David A. Boas "Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses," Neurophotonics 2(3), 035005 (11 September 2015). https://doi.org/10.1117/1.NPh.2.3.035005

Published: 11 September 2015

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