Special Section on Light Microscopy of Connectivity

Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex

[+] Author Affiliations
Brett A. Johnson

University of California–Irvine, Department of Neurobiology and Behavior, 2205 McGaugh Hall, Irvine, California 92697, United States

Ron D. Frostig

University of California–Irvine, Department of Neurobiology and Behavior, 2205 McGaugh Hall, Irvine, California 92697, United States

University of California–Irvine, Department of Biomedical Engineering, 3120 Natural Sciences II, Irvine, California 92697, United States

University of California–Irvine, Center for the Neurobiology of Learning and Memory, 320 Qureshey Research Laboratory, Irvine, California 92697, United States

Neurophoton. 2(4), 041403 (May 27, 2015). doi:10.1117/1.NPh.2.4.041403
History: Received January 29, 2015; Accepted April 20, 2015
Text Size: A A A

Abstract.  Recent years have seen progress in characterizing connections between different regions of the rodent brain to establish a “connectome.” This effort involves systematically collected new data together with tools to characterize network relationships in new and preexisting data. The choices made during data collection, analysis, and display in order to generate these connectomes have emphasized dense, specific connections between cortical regions defined using a priori parcellation schemes that may obscure certain spatial relationships in the data. One example of a pattern of connectivity not clearly evident in these connectomes is a diffusely radiating, apparently nonspecific, border-crossing, long-range horizontal axonal projection that is related to horizontal spreads of evoked activity in the rat cortex. Here, we describe the horizontal projection system and explore evidence for this projection within the connectome data. We consider how the differences in optical and histological methodologies and analyses used for the connectome studies and our own studies lead to different emphases concerning this important horizontal projection pattern.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Topics

Brain ; Axon ; Nerve

Citation

Brett A. Johnson and Ron D. Frostig
"Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex", Neurophoton. 2(4), 041403 (May 27, 2015). ; http://dx.doi.org/10.1117/1.NPh.2.4.041403


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.