Research Papers

Determination of epileptic focus side in mesial temporal lobe epilepsy using long-term noninvasive fNIRS/EEG monitoring for presurgical evaluation

[+] Author Affiliations
Edmi Edison Rizki, Hidenori Yokota, Keiji Oguro

Jichi Medical University, Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

Minako Uga, Ippeita Dan, Daisuke Tsuzuki

Jichi Medical University, Center for Development of Advanced Medical Technology, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

Chuo University, Research and Development Initiatives/Faculty of Science and Engineering, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan

Haruka Dan

Jichi Medical University, Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

Chuo University, Research and Development Initiatives/Faculty of Science and Engineering, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan

Eiju Watanabe

Jichi Medical University, Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

Jichi Medical University, Center for Development of Advanced Medical Technology, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

Neurophoton. 2(2), 025003 (May 20, 2015). doi:10.1117/1.NPh.2.2.025003
History: Received March 25, 2014; Accepted April 10, 2015
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Abstract.  Noninvasive localization of an epileptogenic zone is a fundamental step for presurgical evaluation of epileptic patients. Here, we applied long-term simultaneous functional near-infrared spectroscopy (fNIRS)/electroencephalogram (EEG) monitoring for focus diagnosis in patients with mesial temporal lobe epilepsy (MTLE). Six MTLE patients underwent long-term (8–16 h per day for 4 days) fNIRS/EEG monitoring for the occurrence of spontaneous seizures. Four spontaneous seizures were successfully recorded out of the six patients. To determine oxy-Hb amplitude, the period-average values of oxy-Hb across 20 s from the EEG- or clinically defined epileptic onset were calculated for both hemispheres from the simultaneously recorded fNIRS data. The average oxy-Hb values for the temporal lobe at the earlier EEG- or clinically defined epileptic onsets were greater for the epileptic side than for the contralateral side after EEG activity suppression, spike train, and clinical seizure in all four cases. The true laterality was determined based on the relief of seizures by selective amygdalo-hippocampectomy. Thus, oxy-Hb amplitude could be a reliable measure for determining the epileptic focus side. Long-term simultaneous fNIRS/EEG measurement serves as an effective tool for recording spontaneous seizures. Cerebral hemodynamic measurement by fNIRS would serve as a valuable supplementary noninvasive measurement method for presurgical evaluation of MTLE.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Edmi Edison Rizki ; Minako Uga ; Ippeita Dan ; Haruka Dan ; Daisuke Tsuzuki, et al.
"Determination of epileptic focus side in mesial temporal lobe epilepsy using long-term noninvasive fNIRS/EEG monitoring for presurgical evaluation", Neurophoton. 2(2), 025003 (May 20, 2015). ; http://dx.doi.org/10.1117/1.NPh.2.2.025003


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