Computing microvascular cerebral blood flow () in real cortical angiograms is challenging. Here, we investigated whether the use of Doppler optical coherence tomography (DOCT) flow measurements in individual vessel segments can help in reconstructing across the entire vasculature of a truncated cortical angiogram. A computational framework integrating DOCT measurements is presented. Simulations performed on a synthetic angiogram showed that the addition of DOCT measurements, especially close to large inflowing or outflowing vessels, reduces the impact of pressure boundary conditions and estimated vessel resistances resulting in a more accurate reconstruction of . Our technique was then applied to reconstruct microvascular flow distributions in the mouse cortex down to by combining two-photon laser scanning microscopy angiography with DOCT.