Special Section on the BRAIN Initiative

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

[+] Author Affiliations
Lun-De Liao

National University of Singapore, Singapore Institute for Neurotechnology (SINAPSE), 28 Medical Drive, #05-COR, Singapore 117456, Singapore

Aishwarya Bandla

National University of Singapore, Singapore Institute for Neurotechnology (SINAPSE), 28 Medical Drive, #05-COR, Singapore 117456, Singapore

National University of Singapore, Department of Biomedical Engineering, 9 Engineering Drive 1, Block EA #03-12, Singapore 117575, Singapore

Ji Min Ling

National University of Singapore, Singapore Institute for Neurotechnology (SINAPSE), 28 Medical Drive, #05-COR, Singapore 117456, Singapore

National Neuroscience Institute, Department of Neurosurgery, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore

Yu-Hang Liu

National University of Singapore, Singapore Institute for Neurotechnology (SINAPSE), 28 Medical Drive, #05-COR, Singapore 117456, Singapore

National University of Singapore, Department of Electrical & Computer Engineering, Block E4, Level 5, Room 45, 4 Engineering Drive 3, Singapore 117583, Singapore

Li-Wei Kuo

National Health Research Institutes, Institute of Biomedical Engineering and Nanomedicine, 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan

You-Yin Chen

National Yang Ming University, Department of Biomedical Engineering, No. 155, Sec. 2, Linong St., Taipei, Taiwan 112

Nicolas KK King

National Neuroscience Institute, Department of Neurosurgery, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore

Hsin-Yi Lai

Chang Gung Memorial Hospital and Chang Gung University, Department of Physical Medicine and Rehabilitation, Taoyuan 333, Taiwan

Yan-Ren Lin

Changhua Christian Hospital, Department of Emergency Medicine, 135 Nanshsiao Street, Changhua, Taiwan 500

Nitish V. Thakor

National University of Singapore, Singapore Institute for Neurotechnology (SINAPSE), 28 Medical Drive, #05-COR, Singapore 117456, Singapore

National University of Singapore, Department of Biomedical Engineering, 9 Engineering Drive 1, Block EA #03-12, Singapore 117575, Singapore

National University of Singapore, Department of Electrical & Computer Engineering, Block E4, Level 5, Room 45, 4 Engineering Drive 3, Singapore 117583, Singapore

Johns Hopkins University, Department of Biomedical Engineering, Traylor 701/720 Rutland Avenue, Baltimore, Maryland 21205

Neurophoton. 1(1), 011007 (Jun 19, 2014). doi:10.1117/1.NPh.1.1.011007
History: Received March 10, 2014; Revised May 1, 2014; Accepted May 13, 2014
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Abstract.  Restoring perfusion to the penumbra during the hyperacute phase of ischemic stroke is a key goal of neuroprotection. Thrombolysis is currently the only approved treatment for ischemic stroke. However, its use is limited by the narrow therapeutic window and side effect of bleeding. Therefore, other interventions are desired that could potentially increase the perfusion of the penumbra. Here, we hypothesized that bilateral peripheral electrical stimulation will improve cerebral perfusion and restore cortical neurovascular response. We assess the outcomes of bilateral forepaw electrical stimulation at intensities of 2 and 4 mA, administered either unilaterally or bilaterally. We developed a combined electrocorticogram (ECoG)-functional photoacoustic microscopy (fPAM) system to evaluate the relative changes in cerebral hemodynamic function and electrophysiologic response to acute, focal stroke. The fPAM system is used for cerebral blood volume (CBV) and hemoglobin oxygen saturation (SO2) and the ECoG for neural activity, namely somatosensory-evoked potential (SSEP), interhemispheric coherence, and alpha-delta ratio (ADR) in response to forepaw stimulation. Our results confirmed the neuroprotective effect of bilateral forepaw stimulation at 2 mA as indicated by the 82% recovery of ADR and 95% improvement in perfusion into the region of penumbra. This experimental model can be used to study other potential interventions such as therapeutic hypertension and hypercarbia.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Lun-De Liao ; Aishwarya Bandla ; Ji Min Ling ; Yu-Hang Liu ; Li-Wei Kuo, et al.
"Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model", Neurophoton. 1(1), 011007 (Jun 19, 2014). ; http://dx.doi.org/10.1117/1.NPh.1.1.011007


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